Calcitonin Antibody (CALCA/3310) [Janelia Fluor® 585] Summary
| Immunogen | Recombinant fragment of human Calcitonin protein (around aa 3-116) (exact sequence is proprietary) (Uniprot: P01258 ) |
| Localization | Cytoplasm, Secreted |
| Isotype | IgG2b Kappa |
| Clonality | Monoclonal |
| Host | Mouse |
| Gene | CALCA |
| Purity | Protein A or G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward |
Applications/Dilutions
| Dilutions |
|
| Application Notes | Optimal dilution of this antibody should be experimentally determined. |
Packaging, Storage & Formulations
| Storage | Store at 4C in the dark. |
| Buffer | 50mM Sodium Borate |
| Preservative | 0.05% Sodium Azide |
| Purity | Protein A or G purified |
Notes
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
Alternate Names for Calcitonin Antibody (CALCA/3310) [Janelia Fluor® 585]
- ATP2B2plasma membrane calcium ATPase
- ATPase, Ca++ transporting, plasma membrane 4
- CALC1
- CALCA
- Calcitonin
- DKFZp686G08106
- DKFZp686M088
- EC 3.6.3
- EC 3.6.3.8
- Katacalcin
- Matrix-remodeling-associated protein 1
- matrix-remodelling associated 1
- MXRA1
- PCT
- Plasma membrane calcium ATPase isoform 4
- Plasma membrane calcium pump isoform 4
- plasma membrane calcium pump
- plasma membrane calcium-transporting ATPase 4
- PMCA4b
- PMCA4PMCA4x
- sarcolemmal calcium pump
Background
Calcitonin is a 32 amino acid peptide hormone synthesized by the parafollicular cells of the thyroid. It causes a rapid, but short lived, reduction in serum calcium and phosphate by promoting the incorporation of those ions in the bones. This effect is opposite to that of parathyroid hormone. Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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Product General Protocols
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- Immunohistochemistry-Paraffin
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